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The treatment reduced periorbital wrinkles by 55%, outperforming placebo and vitamin K cream, with 70% of participants reporting improved firmness and clarity (Abdulghani et al., 1998)

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Upon catalysis of COXs, dihomo-γ-linolenic acid (DGLA) and arachidonic acid (AA) can be oxidized by radical-mediated lipid peroxidation and produce prostaglandins, which linking the lipid peroxidation directly to inflammation and apoptotic processes [32,33,34]